Article
Immunopeptidome Analysis of HLA-DPB1 Allelic Variants Reveals New Functional Hierarchies.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2020
van Balen Peter, Kester Michel G D, de Klerk Wendy, Crivello Pietro, Arrieta-Bolaños Esteban, de Ru Arnoud H, Jedema Inge, Mohammed Yassene, Heemskerk Mirjam H M, Fleischhauer Katharina, van Veelen Peter A, Falkenburg J H Frederik
Abstract excerpt
HLA-DP alleles can be classified into functional T cell epitope (TCE) groups. TCE-1 and TCE-2 are clearly defined, but TCE-3 still represents an heterogeneous group. Because polymorphisms in HLA-DP influence the presented peptidome, we investigated whether the composition of peptides binding in HLA-DP may be used to refine the HLA-DP group classification. Peptidomes of human HLA-DP-typed B cell lines were...
Topics
- Alleles
- B-Lymphocytes
- Binding Sites
- Cell Line
- Cell Line, Tumor
- Epitopes, T-Lymphocyte
- HLA-DP beta-Chains
- Hematopoietic Stem Cell Transplantation
- Histocompatibility Testing
- Humans
- K562 Cells
- Peptides