Article
Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation.
The Journal of biological chemistry - 21 Feb 2003
Fluhrer Regina, Multhaup Gerd, Schlicksupp Andrea, Okochi Masayasu, Takeda Masatoshi, Lammich Sven, Willem Michael, Westmeyer Gil, Bode Wolfram, Walter Jochen, Haass Christian
Abstract excerpt
The beta-amyloid precursor protein (beta APP) is proteolytically processed by two secretase activities to produce the pathogenic amyloid beta-peptide (A beta). N-terminal cleavage is mediated by beta-secretase (BACE) whereas C-terminal intramembraneous cleavage is exerted by the presenilin (PS) gamma-secretase complex. The A beta-generating gamma-secretase cleavage principally occurs after amino acid 40 or 42 and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.