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Article

Differential regulation of amyloid precursor protein/presenilin 1 interaction during Aβ40/42 [corrected] production detected using fusion constructs.

PloS one - 1 Jan 2012

Sato Naoyuki, Okochi Masayasu, Shinohara Mitsuru, Thinakaran Gopal, Takeda Shuko, Fukumori Akio, Shinohara-Noma Motoko, Mori-Ueda Mari, Hamada Hizuki, Takeda Masatoshi, Rakugi Hiromi, Morishita Ryuichi

Abstract excerpt

Beta amyloid peptides (Aβ) play a key role in the pathogenesis of Alzheimer disease (AD). Presenilins (PS) function as the catalytic subunits of γ-secretase, the enzyme that releases Aβ from ectodomain cleaved amyloid precursor protein (APP) by intramembrane proteolysis. Familial Alzheimer disease (FAD)-linked PSEN mutations alter APP processing in a manner that increases the relative abundance of longer Aβ42...

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Share to Amyloid beta-Peptides
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23152781
DOI: 10.1371/journal.pone.0048551
PMCID: PMC3495957

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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