Article
Racial variability in haplotype frequencies of UGT1A1 and glucuronidation activity of a novel single nucleotide polymorphism 686C> T (P229L) found in an African-American.
Drug metabolism and disposition: the biological fate of chemicals - 1 Mar 2005
Kaniwa Nahoko, Kurose Kouichi, Jinno Hideto, Tanaka-Kagawa Toshiko, Saito Yoshiro, Saeki Mayumi, Sawada Jun-Ichi, Tohkin Masahiro, Hasegawa Ryuichi
Abstract excerpt
Ethnic differences in genetic polymorphisms in UDP-glucuronosyltransferase 1A1 (UGT1A1) were investigated among African-Americans, Caucasians, and Japanese using samples obtained from 150 individuals for each population. Genotyping of -3279T>G in the phenobarbital-responsive enhancer module, TA repeats in the TATA box, 211G>A (G71R) and 686C>A (P229Q) in exon 1, and three single nucleotide polymorphisms (SNPs)...
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