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Article

Genetic polymorphism in the phenobarbital-responsive enhancer module of the UDP-glucuronosyltransferase 1A1 gene and irinotecan toxicity.

Pharmacogenetics and genomics - 1 Jan 2005

Kitagawa Chiyoe, Ando Maki, Ando Yuichi, Sekido Yoshitaka, Wakai Kenji, Imaizumi Kazuyoshi, Shimokata Kaoru, Hasegawa Yoshinori

Abstract excerpt

Genetic polymorphism of the UDP-glucuronosyltransferase (UGT) 1A1 gene is associated with the decreased glucuronidation activity of an active metabolite of irinotecan, SN-38, and UGT1A1*28 has been shown as a predictive factor for irinotecan toxicity. The phenobarbital-responsive enhancer module (PBREM) of the UGT1A1 promoter region has been reportedly associated with the transcriptional activity of the gene. We...

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Identifiers

PMID: 15864124
DOI: 10.1097/01213011-200501000-00006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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