Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BRCA1 in breast and ovarian cancer predisposition.

Cancer letters - 8 Sept 2005

Billack Blase, Monteiro Alvaro N A

Abstract excerpt

Women carrying one mutated BRCA1 allele are at increased risk of developing breast and ovarian cancer but tumor initiation requires the loss of the wild-type allele indicating that it is a tumor suppressor gene. In the 10 years since the cloning of BRCA1, a function for the gene product in the DNA damage response has been established. However, identifying the exact biochemical activities of BRCA1 has been a more...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to Breast Neoplasms
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, BRCA1

Share to Organ Specificity

Share to Ovarian Neoplasms

Share to Signal Transduction

Share to Ubiquitin

Source

Identifiers

PMID: 16051027
DOI: 10.1016/j.canlet.2004.11.006

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BRCA1 in breast and ovarian cancer predisposition.PMID 16051027Read ↗

BRCA1 gene in breast cancer.Semantic proximity Read ↗

Molecular functions of BRCA1 in the DNA damage response.Semantic proximity Read ↗

Understanding the functions of BRCA1 in the DNA-damage response.Semantic proximity Read ↗

BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution.Semantic proximity Read ↗

BRCA1: mechanisms of inactivation and implications for management of patients.Semantic proximity Read ↗

BRCA1, a gene involved in inherited predisposition to breast and ovarian cancer.Semantic proximity Read ↗

Emerging roles of BRCA1 in transcriptional regulation and DNA repair.Semantic proximity Read ↗

Roles of BRCA1 in DNA damage repair: a link between development and cancer.Semantic proximity Read ↗

The role of BRCA1 in DNA damage response.Semantic proximity Read ↗

In brief: BRCA1 and BRCA2.Semantic proximity Read ↗

BRCA1 16 years later: risk-associated BRCA1 mutations and their functional implications.Semantic proximity Read ↗

The functions of breast cancer susceptibility gene 1 (BRCA1) product and its associated proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.