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Enhanced cancer cell proliferation and aggressive phenotype counterbalance in breast cancer with high BRCA1 gene expression.

Breast cancer research and treatment - 1 Nov 2024

Chida Kohei, Oshi Masanori, Roy Arya Mariam, Sato Takumi, Takabe Maya Penelope, Yan Li, Endo Itaru, Hakamada Kenichi, Takabe Kazuaki

Abstract excerpt

PURPOSE: While comprehensive research exists on the mutation of the DNA repair gene BRCA1, limited information is available regarding the clinical significance of BRCA1 gene expression. Given that cancer cell proliferation is aggrevated by DNA repair, we hypothesized that high BRCA1 gene expression breast cancer (BC) might be linked with aggressive tumor biology and poor clinical outcomes. METHODS: The cohorts:...

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Identifiers

PMID: 38972017
DOI: 10.1007/s10549-024-07421-8

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