Article
BRCA1/2 mutations perturb telomere biology: characterization of structural and functional abnormalities in vitro and in vivo.
Oncotarget - 19 Jan 2016
Uziel Orit, Yerushalmi Rinat, Zuriano Lital, Naser Shaden, Beery Einat, Nordenberg Jardena, Lubin Ido, Adel Yonatan, Shepshelovich Daniel, Yavin Hagai, Ben Aharon Irit, Pery Shlomit, Rizel Shulamit, Pasmanik-Chor Metsada, Frumkin Dan, Lahav Meir
Abstract excerpt
BRCA1 mutation is associated with carcinogenesis, especially of breast tissue. Telomere maintenance is crucial for malignant transformation. Being a part of the DNA repair machinery, BRCA1 may be implicated in telomere biology. We explored the role of BRCA1 in telomere maintenance in lymphocytes of BRCA1/2 mutation carriers and in in vitro system by knocking down its expression in non-malignant breast epithelial...
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