Article
Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate.
Cell stem cell - 4 Feb 2011
Proia Theresa A, Keller Patricia J, Gupta Piyush B, Klebba Ina, Jones Ainsley D, Sedic Maja, Gilmore Hannah, Tung Nadine, Naber Stephen P, Schnitt Stuart, Lander Eric S, Kuperwasser Charlotte
Abstract excerpt
Women with inherited mutations in the BRCA1 gene have increased risk of developing breast cancer but also exhibit a predisposition for the development of aggressive basal-like breast tumors. We report here that breast epithelial cells derived from patients harboring deleterious mutations in BRCA1 (BRCA1(mut /+) give rise to tumors with increased basal differentiation relative to cells from BRCA1+/+ patients....
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