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Article

Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans.

Nature genetics - 1 Aug 2005

Hillebrandt Sonja, Wasmuth Hermann E, Weiskirchen Ralf, Hellerbrand Claus, Keppeler Hildegard, Werth Alexa, Schirin-Sokhan Ramin, Wilkens Gabriele, Geier Andreas, Lorenzen Johann, Köhl Jörg, Gressner Axel M, Matern Siegfried, Lammert Frank

Abstract excerpt

Fibrogenesis or scarring of the liver is a common consequence of all chronic liver diseases. Here we refine a quantitative trait locus that confers susceptibility to hepatic fibrosis by in silico mapping and show, using congenic mice and transgenesis with recombined artificial chromosomes, that the gene Hc (encoding complement factor C5) underlies this locus. Small molecule inhibitors of the C5a receptor had...

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PMID: 15995705
DOI: 10.1038/ng1599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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