Article

A Tale of Two Mice: genetics of model mouse strains suggest a transcriptional basis for risk and resistance in idiopathic pulmonary fibrosis

2024-11-11

Abstract excerpt

<title>Abstract</title> <p>Background Idiopathic pulmonary fibrosis (IPF) is a terminal inflammatory lung disease that causes permanent scarring (fibrogenesis). Bleomycin (BLM) is a drug used to induce fibrosis in mouse models, typically C57BL/6. However, meta-analyses show inter-strain heterogeneity in response, e.g. resistance in BALB/c. This study extends transcriptomic analysis of IPF to a resistant strain,...

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Literature Corpus work: e10b8198-9c80-5103-b605-6e49083c1e12
DOI: 10.21203/rs.3.rs-5295459/v1

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