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Article

The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted.

The Journal of biological chemistry - 28 Feb 2003

Grziwa Beate, Grimm Marcus O W, Masters Colin L, Beyreuther Konrad, Hartmann Tobias, Lichtenthaler Stefan F

Abstract excerpt

The amyloid precursor protein is cleaved within its ectodomain by beta-amyloid-converting enzyme (BACE) yielding C99, which is further cleaved by gamma-secretase within its putative transmembrane domain (TMD). Because it is difficult to envisage how a protease may cleave within the membrane, alternative mechanisms have been proposed for gamma-cleavage in which the TMD is shorter than predicted or positioned such...

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PMID: 12454010
DOI: 10.1074/jbc.M210047200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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