Article
Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2002
Hwang Dae Y, Chae Kab R, Kang Tae S, Hwang Jin H, Lim Chae H, Kang Hyun K, Goo Jun S, Lee Mi R, Lim Hwa J, Min Sae H, Cho Jun Y, Hong Jin T, Song Chi W, Paik Sang G, Cho Jung S, Kim Yong K
Abstract excerpt
Alzheimer's disease (AD) occurs when neurons in the memory and cognition regions of the brain are accompanied by an accumulation of the long amyloid beta-proteins of the 39 to 43 amino acids derived from the amyloid precursor protein (APP) by cleavage with beta- and gamma-secretase. An increased production of Abeta-42 by mutation of PS2 genes promotes caspase expression and is associated with the Cox-2 found in...
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