Article
Mammary tumor modifiers in BALB/cJ mice heterozygous for p53.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 May 2007
Koch Joanna G, Gu Xiangjun, Han Younghun, El-Naggar Adel K, Olson Melissa V, Medina Daniel, Jerry D Joseph, Blackburn Anneke C, Peltz Gary, Amos Christopher I, Lozano Guillermina
Abstract excerpt
BALB/c mice are predisposed to developing spontaneous mammary tumors, which are further increased in a p53 heterozygous state. C57BL/6J mice are resistant to induced mammary tumors and develop less than 1% mammary tumors in both wild-type and p53+/- states. To map modifiers of mammary tumorigenesis, we have established F1 and F2 crosses and backcrosses to BALB/cJ (N2-BALB/cJ) and C57BL/6J (N2-C57BL/6J) strains....
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