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Polymorphism in the manganese superoxide dismutase gene.

Free radical research - 1 Jul 2007

Elsakka Noha E, Webster Nigel R, Galley Helen F

Abstract excerpt

Oxidative stress and mitochondrial damage occur in sepsis. Manganese superoxide dismutase (MnSOD) provides the main defence against oxidative stress within mitochondria. Ala9Val is a single nucleotide polymorphism (SNP) in the MnSOD gene, predicted to affect intra-mitochondrial transport of the enzyme. We found a significant difference in the genotype frequency between healthy subjects (n = 100) and patients with...

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PMID: 17577737
DOI: 10.1080/10715760701338828

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