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Article

Analysis of clonotypic switch junctions reveals multiple myeloma originates from a single class switch event with ongoing mutation in the isotype-switched progeny.

Blood - 1 Sept 2008

Taylor Brian J, Kriangkum Jitra, Pittman Julie A, Mant Michael J, Reiman Tony, Belch Andrew R, Pilarski Linda M

Abstract excerpt

Multiple myeloma (MM) is a cancer of plasma cells (PCs) expressing immunoglobulin heavy chain (IgH) postswitch isotypes. The discovery of earlier stage cells related to postswitch PCs, called preswitch clonotypic IgM (cIgM) cells led to the hypothesis that cIgM cells may be MM progenitors, replenishing the tumor throughout malignancy. cIgM cells may do this by undergoing class switch recombination (CSR), a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Sequence Homology, Nucleic Acid

Share to Somatic Hypermutation, Immunoglobulin

Source

Identifiers

PMID: 18577707
DOI: 10.1182/blood-2008-01-129221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Analysis of clonotypic switch junctions reveals multiple myeloma originates from a single class switch event with ongoing mutation in the isotype-switched progeny.PMID 18577707Read ↗

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