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Article

Double productive immunoglobulin sequence rearrangements in patients with chronic lymphocytic leukemia.

American journal of hematology - 1 Apr 2013

Visco Carlo, Moretta Francesca, Falisi Erika, Facco Monica, Maura Francesco, Novella Elisabetta, Nichele Ilaria, Finotto Silvia, Giaretta Ilaria, Ave Elisa, Perbellini Omar, Guercini Nicola, Scupoli Maria Teresa, Trentin Livio, Trimarco Valentina, Neri Antonino, Semenzato Gianpietro, Rodeghiero Francesco, Pizzolo Giovanni, Ambrosetti Achille

Abstract excerpt

The immunoglobulin heavy chain variable (IGHV) gene mutational status represents a major prognostic marker in chronic lymphocytic leukemia (CLL). Usually, the prognostic implications of IGHV gene analysis can be reliably ascertained but, occasionally, double productive rearrangements have been detected. Clinical presentation and biological features of such cases are unknown. Sixty patients with morphologically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Identifiers

PMID: 23450508
DOI: 10.1002/ajh.23396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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