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Article

The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance.

Neuron - 24 Jun 2004

Lee Haeryun, Engel Ulrike, Rusch Jannette, Scherrer Simone, Sheard Katherine, Van Vactor David

Abstract excerpt

Axon guidance requires coordinated remodeling of actin and microtubule polymers. Using a genetic screen, we identified the microtubule-associated protein Orbit/MAST as a partner of the Abelson (Abl) tyrosine kinase. We find identical axon guidance phenotypes in orbit/MAST and Abl mutants at the midline, where the repellent Slit restricts axon crossing. Genetic interaction and epistasis assays indicate that...

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Identifiers

PMID: 15207236
DOI: 10.1016/j.neuron.2004.05.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance.PMID 15207236Read ↗

Parallel genetic and proteomic screens identify Msps as a CLASP-Abl pathway interactor in Drosophila.Semantic proximity Read ↗

A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding.Semantic proximity Read ↗

MAST/Orbit has a role in microtubule-kinetochore attachment and is essential for chromosome alignment and maintenance of spindle bipolarity.Semantic proximity Read ↗

The transmembrane protein Off-track associates with Plexins and functions downstream of Semaphorin signaling during axon guidance.Semantic proximity Read ↗

The Drosophila abrupt gene encodes a BTB-zinc finger regulatory protein that controls the specificity of neuromuscular connections.Semantic proximity Read ↗

Abelson tyrosine kinase is required to transduce midline repulsive cues.Semantic proximity Read ↗

Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding.Semantic proximity Read ↗

Mask, the <i>Drosophila</i> Ankyrin Repeat and KH domain-containing protein, regulates microtubule dynamicsSemantic proximity Read ↗

The Abelson tyrosine kinase, the Trio GEF and Enabled interact with the Netrin receptor Frazzled in Drosophila.Semantic proximity Read ↗

The Abl pathway bifurcates to balance Enabled and Rac signaling in axon patterning in Drosophila.Semantic proximity Read ↗

Orbit/Mast, the CLASP orthologue of Drosophila, is required for asymmetric stem cell and cystocyte divisions and development of the polarised microtubule network that interconnects oocyte and nurse cells during oogenesis.Semantic proximity Read ↗

The armadillo family of structural proteins.Semantic proximity Read ↗

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