Article
Gene expression profiling of isogenic cells with different TP53 gene dosage reveals numerous genes that are affected by TP53 dosage and identifies CSPG2 as a direct target of p53.
Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 2002
Yoon Heejei, Liyanarachchi Sandya, Wright Fred A, Davuluri Ramana, Lockman Janet C, de la Chapelle Albert, Pellegata Natalia S
Abstract excerpt
TP53 does not fully comply with the Knudson model [Knudson, A. G., Jr. (1971) Proc. Natl. Acad. Sci. USA 68, 820-823] in that a reduction of constitutional expression of p53 may be sufficient for tumor predisposition. This finding suggests a gene-dosage effect for p53 function. To determine wheth...
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