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Article

The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice.

Developmental biology - 1 Jul 2011

Billington Charles J, Ng Brandon, Forsman Cynthia, Schmidt Brian, Bagchi Anindya, Symer David E, Schotta Gunnar, Gopalakrishnan Rajaram, Sarver Aaron L, Petryk Anna

Abstract excerpt

The severity of numerous developmental abnormalities can vary widely despite shared genetic causes. Mice deficient in Twisted gastrulation (Twsg1(-/-)) display such phenotypic variation, developing a wide range of craniofacial malformations on an isogenic C57BL/6 strain background. To examine the molecular basis for this reduced penetrance and variable expressivity, we used exon microarrays to analyze gene...

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Identifiers

PMID: 21549111
DOI: 10.1016/j.ydbio.2011.04.026
PMCID: PMC3105466

Genes

TWSG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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