Article
p53 isoforms can regulate p53 transcriptional activity.
Genes & development - 15 Sept 2005
Bourdon Jean-Christophe, Fernandes Kenneth, Murray-Zmijewski Fiona, Liu Geng, Diot Alexandra, Xirodimas Dimitris P, Saville Mark K, Lane David P
Abstract excerpt
The recently discovered p53-related genes, p73 and p63, express multiple splice variants and N-terminally truncated forms initiated from an alternative promoter in intron 3. To date, no alternative promoter and multiple splice variants have been described for the p53 gene. In this study, we show that p53 has a gene structure similar to the p73 and p63 genes. The human p53 gene contains an alternative promoter and...
Topics
- Alternative Splicing
- Animals
- Apoptosis
- Breast Neoplasms
- Cell Line, Tumor
- Drosophila
- Evolution, Molecular
- Gene Expression Regulation, Neoplastic
- Genes, Insect
- Genes, Reporter
- Genes, p53
- Genetic Variation
- HT29 Cells