Article

Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration

2024-11-15

Abstract excerpt

During cancer development and progression, many genetic alterations lead to the acquisition of novel features that confer selective advantage to cancer cells and that resemble developmental programs. SOX2 is one of the key pluripotency transcription factors, expressed during embryonic development and active in adult stem cells. In cancer, SOX2 is frequently dysregulated and associated with tumor stemness and poor...

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Literature Corpus work: 64c895d8-1f26-573e-bd71-b4e9f6378fd0
DOI: 10.1101/2024.11.14.623640

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