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Isolation of p53‐target genes and their functional analysis

1 Jan 2004

Abstract excerpt

Mutations of the p53 gene are the most common genetic alterations found in human cancers, and are known to play crucial roles in tumor development and progression. The p53 gene encodes a protein functioning as a transcription factor, and the biological functions of p53 are manifested through the activities of its downstream genes. Identification of these downstream genes involved in the p53-signaling pathway...

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PMID: 14720320
DOI: 10.1111/j.1349-7006.2004.tb03163.x

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