Article
Mutational analysis of the PRP4 protein of Saccharomyces cerevisiae suggests domain structure and snRNP interactions.
Nucleic acids research - 11 May 1994
Hu J, Xu Y, Schappert K, Harrington T, Wang A, Braga R, Mogridge J, Friesen J D
Abstract excerpt
The PRP4 protein of Saccharomyces cerevisiae is an essential part of the U4/U6 snRNP, a component of the mRNA splicing apparatus. As an approach to the determination of structure-function relationships in the PRP4 protein, we have isolated more than fifty new alleles of the PRP4 gene through rand...
Topics
- Amino Acid Sequence
- Base Sequence
- DNA, Fungal
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Phenotype
- Point Mutation
- Protein Conformation
- Protein Serine-Threonine Kinases
- RNA Splicing
- RNA Splicing Factors
- Ribonucleoprotein, U4-U6 Small Nuclear
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins