The molecular characterization of PRP6 and PRP9 yeast genes reveals a new cysteine/histidine motif common to several splicing factors.

doi:10.1002/j.1460-2075.1990.tb07465.x

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Article

The molecular characterization of PRP6 and PRP9 yeast genes reveals a new cysteine/histidine motif common to several splicing factors.

The EMBO journal - 1 Sept 1990

Legrain P, Choulika A

Abstract excerpt

prp6 and prp9 thermosensitive (ts) mutants are affected in pre-mRNA splicing and transport from the nucleus to the cytoplasm. PRP6 and PRP9 wild-type alleles have been sequenced. DNA sequence analysis reveals homologies in the 5' and 3' non-coding regions, suggesting a common regulation of gene expression. PRP6 and PRP9 genes encode a 899 amino acid and a 530 amino acid protein, respectively. The PRP6 protein has...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Cysteine
DNA, Fungal
DNA-Binding Proteins
Fungal Proteins
Genes, Fungal
Humans
Metalloproteins
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Plasmids

Protein Conformation

RNA Splicing

RNA Splicing Factors

RNA-Binding Proteins

Restriction Mapping

Source

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Identifiers

PMID: 2118103
DOI: 10.1002/j.1460-2075.1990.tb07465.x
PMCID: PMC551986

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2118103-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The molecular characterization of PRP6 and PRP9 yeast genes reveals a new cysteine/histidine motif common to several splicing factors.PMID 2118103Read ↗

Cloning of the two essential yeast genes, PRP6 and PRP9, and their rapid mapping, disruption and partial sequencing using a linker insertion strategy.Semantic proximity Read ↗

A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family.Semantic proximity Read ↗

Extragenic suppressors of Saccharomyces cerevisiae prp4 mutations identify a negative regulator of PRP genes.Semantic proximity Read ↗

Thermoconditional modulation of the pleiotropic sensitivity phenotype by the Saccharomyces cerevisiae PRP19 mutant allele pso4-1.Semantic proximity Read ↗

Interactions between PRP9 and SPP91 splicing factors identify a protein complex required in prespliceosome assembly.Semantic proximity Read ↗

Mutational analysis of the PRP4 protein of Saccharomyces cerevisiae suggests domain structure and snRNP interactions.Semantic proximity Read ↗

Six novel genes necessary for pre-mRNA splicing in Saccharomyces cerevisiae.Semantic proximity Read ↗

The prp1+ gene required for pre-mRNA splicing in Schizosaccharomyces pombe encodes a protein that contains TPR motifs and is similar to Prp6p of budding yeast.Semantic proximity Read ↗

Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation.Semantic proximity Read ↗

An extragenic suppressor of prp24-1 defines genetic interaction between PRP24 and PRP21 gene products of Saccharomyces cerevisiae.Semantic proximity Read ↗

spp42, identified as a classical suppressor of prp4-73, which encodes a kinase involved in pre-mRNA splicing in fission yeast, is a homologue of the splicing factor Prp8p.Semantic proximity Read ↗

Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation.Semantic proximity Read ↗

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