Article
Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass.
The Journal of biological chemistry - 17 Jan 2003
Gowen Lori C, Petersen Donna N, Mansolf Amy L, Qi Hong, Stock Jeffrey L, Tkalcevic George T, Simmons Hollis A, Crawford David T, Chidsey-Frink Kristen L, Ke Hua Zhu, McNeish John D, Brown Thomas A
Abstract excerpt
We have previously described osteoblast/osteocyte factor 45 (OF45), a novel bone-specific extracellular matrix protein, and demonstrated that its expression is tightly linked to mineralization and bone formation. In this report, we have cloned and characterized the mouse OF45 cDNA and genomic region. Mouse OF45 (also called MEPE) was similar to its rat orthologue in that its expression was increased during...
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