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Article

Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 2005

Lane Nancy E, Yao Wei, Nakamura Mary C, Humphrey Mary Beth, Kimmel Donald, Huang Xiaozhu, Sheppard Dean, Ross F Patrick, Teitelbaum Steven L

Abstract excerpt

UNLABELLED: Integrin alphavbeta5 is expressed on osteoclast precursors and is capable of recognizing the same amino acid motif as alphavbeta3. Three-month-old beta5(-/-) female OVX mice had increased osteoclastogenesis ex vivo, and microCT assessment of trabecular bone volume was 53% lower than WT-OVX animals. These preliminary data suggest alphavbeta5 integrin's presence on osteoclast precursors may inhibit of...

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Identifiers

PMID: 15619670
DOI: 10.1359/JBMR.041017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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