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Article

SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells.

Science (New York, N.Y.) - 25 Nov 2005

Reddien Peter W, Oviedo Néstor J, Jennings Joya R, Jenkin James C, Sánchez Alvarado Alejandro

Abstract excerpt

We have identified two genes, smedwi-1 and smedwi-2, expressed in the dividing adult stem cells (neoblasts) of the planarian Schmidtea mediterranea. Both genes encode proteins that belong to the Argonaute/PIWI protein family and that share highest homology with those proteins defined by Drosophila PIWI. RNA interference (RNAi) of smedwi-2 blocks regeneration, even though neoblasts are present,...

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Identifiers

PMID: 16311336
DOI: 10.1126/science.1116110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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