Article
Study of the nematode putative GABA type-A receptor subunits: evidence for modulation by ivermectin.
Journal of neurochemistry - 1 Nov 2002
Feng Xiao-Peng, Hayashi Jon, Beech Robin N, Prichard Roger K
Abstract excerpt
Two alleles of the HG1 gene, which encodes a putative GABA receptor alpha/gamma subunit, were isolated from Haemonchus contortus. These two alleles were shown previously to be associated with ivermectin susceptibility (HG1A) and resistance (HG1E), respectively. Sequence analysis indicates that they differ in four amino acids. To explore the functional properties of the two alleles, a full-length cDNA encoding the...
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