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Article

Dominance of P-glycoprotein 12 in phenotypic resistance conversion against ivermectin in Caenorhabditis elegans.

PloS one - 1 Jan 2018

Figueiredo Luiza Almeida, Rebouças Thais Fuscaldi, Ferreira Sebastião Rodrigo, Rodrigues-Luiz Gabriela Flavia, Miranda Rodrigo Cambraia, Araujo Ricardo Nascimento, Fujiwara Ricardo Toshio

Abstract excerpt

While diseases caused by nematodes remains a considerable drawback for the livestock, agriculture and public health, anthelmintics drug resistance has been observed over the past years and is a major concern for parasite control. Ivermectin, initially considered as a highly potent drug, currently presents a reduced anti-helminthic efficacy, which is influenced by expression of several ATP-binding cassette...

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Identifiers

PMID: 29474375
DOI: 10.1371/journal.pone.0192995
PMCID: PMC5825046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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