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Article

G-protein-coupled receptor genes of Dirofilaria immitis.

Molecular and biochemical parasitology - 1 Jun 2018

Mani Thangadurai, Bourguinat Catherine, Prichard Roger K

Abstract excerpt

The diversity and uniqueness of nematode heterotrimeric G-protein-coupled receptors (GPCRs) provides impetus for identifying ligands that can be used as therapeutics for treating diseases caused by parasitic nematode infections. In human medicine, GPCRs have represented the largest group of 'drugable' targets exploited in the market today. In the filarial nematode Dirofilaria immitis, which causes heartworm...

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PMID: 29625152
DOI: 10.1016/j.molbiopara.2018.04.001

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