The <i>Dirofilaria immitis unc-49</i> gene encodes a pharmacologically unique cys-loop GABA receptor

Abstract excerpt

Nematode cys-loop GABA receptors play important roles in movement and locomotion. GABA receptors encoded by unc-49 appear to be widespread in nematode genomes including parasitic nematodes but are poorly characterized in filarial parasites. Dirofilaria immitis is a filarial parasite responsible for heartworm disease in dogs. Macrocyclic lactones are widely used to prevent heartworm infection. However, like many...

Topics

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• Anthelmintics
• Drug Design
• Genome, Helminth
• Helminth Proteins
• Ion Channels
• Multigene Family
• Polymorphism, Single Nucleotide
• Receptors, G-Protein-Coupled

Identifiers and source

Literature Corpus work

9dde0e58-b2ac-55c5-9b99-a13bfe257bed

DOI

10.1101/2025.10.30.685166