Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An ivermectin-sensitive glutamate-gated chloride channel from the parasitic nematode Haemonchus contortus.

Molecular pharmacology - 1 Jun 2009

McCavera Samantha, Rogers Adrian T, Yates Darran M, Woods Debra J, Wolstenholme Adrian J

Abstract excerpt

Nematode glutamate-gated chloride channels are targets of the macrocyclic lactones, the most important group of anthelmintics available. In Xenopus laevis oocytes, channels formed by the GluClalpha3B subunit from the parasite Haemonchus contortus were more sensitive to l-glutamate (EC(50) = 27.6 +/- 2.7 microM) than those formed by the homologous subunit from Caenorhabditis elegans (EC(50) = 2.2 +/- 0.12 mM)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anthelmintics
Share to Chloride Channel Agonists

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chloride Channels

Share to Haemonchus

Share to Ion Channel Gating

Share to Ivermectin

Share to Radioligand Assay

Share to Xenopus laevis

Source

Open in PubMed Open full text

Identifiers

PMID: 19336526
DOI: 10.1124/mol.108.053363
PMCID: PMC2684884

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An ivermectin-sensitive glutamate-gated chloride channel from the parasitic nematode Haemonchus contortus.PMID 19336526Read ↗

Functional investigation of conserved glutamate receptor subunits reveals a new mode of action of macrocyclic lactones in nematodesSemantic proximity Read ↗

Characterization of glutamate-gated chloride channels in the pharynx of wild-type and mutant Caenorhabditis elegans delineates the role of the subunit GluCl-alpha2 in the function of the native receptor.Semantic proximity Read ↗

Mutations in the extracellular domains of glutamate-gated chloride channel alpha3 and beta subunits from ivermectin-resistant Cooperia oncophora affect agonist sensitivity.Semantic proximity Read ↗

Molecular determinants of ivermectin sensitivity at the glycine receptor chloride channel.Semantic proximity Read ↗

Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortus.Semantic proximity Read ↗

Pharmacological effects of ivermectin, an antiparasitic agent for intestinal strongyloidiasis: its mode of action and clinical efficacy.Semantic proximity Read ↗

Subunit stoichiometry and arrangement in a heteromeric glutamate-gated chloride channel.Semantic proximity Read ↗

An L319F mutation in transmembrane region 3 (TM3) selectively reduces sensitivity to okaramine B of the Bombyx mori l-glutamate-gated chloride channel.Semantic proximity Read ↗

Genetic and biochemical evidence for a novel avermectin-sensitive chloride channel in Caenorhabditis elegans. Isolation and characterization.Semantic proximity Read ↗

Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin.Semantic proximity Read ↗

An engineered glutamate-gated chloride (GluCl) channel for sensitive, consistent neuronal silencing by ivermectin.Semantic proximity Read ↗

Genetic variability of glutamate-gated chloride channel genes in ivermectin-susceptible and -resistant strains of Cooperia oncophora.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.