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Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and recovery in a parasitic nematode

2021-11-12

Abstract excerpt

The antiparasitic drug ivermectin plays an essential role in human and animal health globally. However, ivermectin resistance is widespread in veterinary helminths and there are growing concerns of sub-optimal responses to treatment in related helminths of humans. Despite decades of research, the genetic mechanisms underlying ivermectin resistance are poorly understood in parasitic helminths. This reflects signifi...

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Literature Corpus work
55f198de-1756-5c7e-83f4-05264951974a
DOI
10.1101/2021.11.12.468372
Open publication

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Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and recovery in a parasitic nematodeDOI 10.1101/2021.11.12.468372
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