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Article

cGMP-mediated signaling via cGKIalpha is required for the guidance and connectivity of sensory axons.

The Journal of cell biology - 11 Nov 2002

Schmidt Hannes, Werner Matthias, Heppenstall Paul A, Henning Mechthild, Moré Margret I, Kühbandner Susanne, Lewin Gary R, Hofmann Franz, Feil Robert, Rathjen Fritz G

Abstract excerpt

Previous in vitro studies using cGMP or cAMP revealed a cross-talk between signaling mechanisms activated by axonal guidance receptors. However, the molecular elements modulated by cyclic nucleotides in growth cones are not well understood. cGMP is a second messenger with several distinct targets including cGMP-dependent protein kinase I (cGKI). Our studies indicated that the alpha isoform of cGKI is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12417579
DOI: 10.1083/jcb.200207058
PMCID: PMC2173065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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