Article
Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons.
Cell - 30 May 2003
Graef Isabella A, Wang Fan, Charron Frederic, Chen Lei, Neilson Joel, Tessier-Lavigne Marc, Crabtree Gerald R
Abstract excerpt
Axon outgrowth is the first step in the formation of neuronal connections, but the pathways that regulate axon extension are still poorly understood. We find that mice deficient in calcineurin-NFAT signaling have dramatic defects in axonal outgrowth, yet have little or no defect in neuronal differentiation or survival. In vitro, sensory and commissural neurons lacking calcineurin function or NFATc2, c3, and c4...
Topics
- Active Transport, Cell Nucleus
- Animals
- Calcineurin
- Calcineurin Inhibitors
- Cell Differentiation
- Cells, Cultured
- DNA-Binding Proteins
- Gene Expression Regulation, Developmental
- Growth Cones
- Growth Substances
- Mice
- Mutation
- NFATC Transcription Factors