Article
The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord.
The Journal of cell biology - 22 Oct 2007
Schmidt Hannes, Stonkute Agne, Jüttner René, Schäffer Susanne, Buttgereit Jens, Feil Robert, Hofmann Franz, Rathjen Fritz G
Abstract excerpt
Sensory axonal projections into the spinal cord display a highly stereotyped pattern of T- or Y-shaped axon bifurcation at the dorsal root entry zone (DREZ). Here, we provide evidence that embryonic mice with an inactive receptor guanylyl cyclase Npr2 or deficient for cyclic guanosine monophosphate-dependent protein kinase I (cGKI) lack the bifurcation of sensory axons at the DREZ, i.e., the ingrowing axon either...
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