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Article

The tumor suppressor p53 transcriptionally regulates cGKI expression during neuronal maturation and is required for cGMP-dependent growth cone collapse.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Dec 2009

Tedeschi Andrea, Nguyen Tuan, Steele Sonya Ulrike, Feil Susanne, Naumann Ulrike, Feil Robert, Di Giovanni Simone

Abstract excerpt

The cGMP-dependent protein kinase type I (cGKI) has multiple functions including a role in axonal growth and pathfinding of sensory neurons, and counteracts Semaphorin 3A (Sema3A)-induced growth cone collapse. Within the nervous system, however, the transcriptional regulation of cGKI is still obscure. Recently, the transcription factor and tumor suppressor p53 has been reported to promote neurite outgrowth by...

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Identifiers

PMID: 19955367
DOI: 10.1523/JNEUROSCI.4416-09.2009
PMCID: PMC2822954

Genes

PC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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