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Article

Ubc9 is essential for viability of higher eukaryotic cells.

Experimental cell research - 1 Nov 2002

Hayashi Tomoko, Seki Masayuki, Maeda Daisuke, Wang Wensheng, Kawabe Yoh-ichi, Seki Takahiko, Saitoh Hisato, Fukagawa Tatsuo, Yagi Hideki, Enomoto Takemi

Abstract excerpt

Ubc9 is an enzyme involved in the conjugation of SUMO-1 (small ubiquitin related modifier 1) to target proteins. The SUMO-1 conjugation system is well conserved from yeasts to higher eukaryotes, but many SUMO-1 target proteins reported recently in higher eukaryotic cells, including IkappaBalpha, MDM2, p53, and PML, are not present in yeasts. To determine the physiological roles of SUMO-1 conjugation in higher...

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Identifiers

PMID: 12413887
DOI: 10.1006/excr.2002.5634

Genes

MDM2
PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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