Article
Characterization of the loss of SUMO pathway function on cancer cells and tumor proliferation.
PloS one - 1 Jan 2015
He Xingyue, Riceberg Jessica, Pulukuri Sai M, Grossman Steve, Shinde Vaishali, Shah Pooja, Brownell James E, Dick Larry, Newcomb John, Bence Neil
Abstract excerpt
SUMOylation is a post-translational ubiquitin-like protein modification pathway that regulates important cellular processes including chromosome structure, kinetochore function, chromosome segregation, nuclear and sub-nuclear organization, transcription and DNA damage repair. There is increasing evidence that the SUMO pathway is dysregulated in cancer, raising the possibility that modulation of this pathway may...
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