Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of the loss of SUMO pathway function on cancer cells and tumor proliferation.

PloS one - 1 Jan 2015

He Xingyue, Riceberg Jessica, Pulukuri Sai M, Grossman Steve, Shinde Vaishali, Shah Pooja, Brownell James E, Dick Larry, Newcomb John, Bence Neil

Abstract excerpt

SUMOylation is a post-translational ubiquitin-like protein modification pathway that regulates important cellular processes including chromosome structure, kinetochore function, chromosome segregation, nuclear and sub-nuclear organization, transcription and DNA damage repair. There is increasing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Cell Cycle Checkpoints
Share to Cellular Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to Heterografts

Share to Small Ubiquitin-Related Modifier Proteins

Share to Sumoylation

Share to Tumor Burden

Source

Open in PubMed Open full text

Identifiers

PMID: 25860128
DOI: 10.1371/journal.pone.0123882
PMCID: PMC4393225

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25860128-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of the loss of SUMO pathway function on cancer cells and tumor proliferation.PMID 25860128Read ↗

Targeting SUMO Signaling to Wrestle CancerSemantic proximity Read ↗

Therapeutic Potential of Targeting the SUMO Pathway in CancerSemantic proximity Read ↗

The post-translational modification, SUMOylation, and cancer (Review)Semantic proximity Read ↗

SUMO modification of Stra13 is required for repression of cyclin D1 expression and cellular growth arrest.Semantic proximity Read ↗

A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven TumorigenesisSemantic proximity Read ↗

Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphomaSemantic proximity Read ↗

Dual inhibition of SUMOylation and MEK conquers MYC-expressing KRAS-mutant cancers by accumulating DNA damage.Semantic proximity Read ↗

Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma.Semantic proximity Read ↗

Sumoylation in Physiology, Pathology and TherapySemantic proximity Read ↗

SUMO targets the APC/C to regulate transition from metaphase to anaphaseSemantic proximity Read ↗

Targeting protein hyper-SUMOylation halts cholangiocarcinoma progression by impairing cancer cell viability and tumor-stroma cross talkSemantic proximity Read ↗

The SUMO Family: Mechanisms and Implications in Thyroid Cancer Pathogenesis and TherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.