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Article

Ubc9 Is Required for Positive Selection and Late-Stage Maturation of Thymocytes.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2017

Wang Aibo, Ding Xiao, Demarque Maud, Liu Xindong, Pan Deng, Xin Huawei, Zhong Bo, Wang Xiaohu, Dejean Anne, Jin Wei, Dong Chen

Abstract excerpt

SUMOylation is an important posttranslational modification that regulates protein function in diverse biological processes. However, its role in early T cell development has not been genetically studied. UBC9 is the only E2 enzyme for all SUMOylation. In this study, by selectively deleting Ubc9 gene in T cells, we have investigated the functional roles of SUMOylation in T cell development. Loss of Ubc9 results in...

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Identifiers

PMID: 28314856
DOI: 10.4049/jimmunol.1600980
PMCID: PMC5392730

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