Article
Mammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cell survival, and homologous recombinational repair.
Molecular and cellular biology - 1 Mar 2006
Pandita Raj K, Sharma Girdhar G, Laszlo Andrei, Hopkins Kevin M, Davey Scott, Chakhparonian Mikhail, Gupta Arun, Wellinger Raymund J, Zhang Junran, Powell Simon N, Roti Roti Joseph L, Lieberman Howard B, Pandita Tej K
Abstract excerpt
The protein products of several rad checkpoint genes of Schizosaccharomyces pombe (rad1+, rad3+, rad9+, rad17+, rad26+, and hus1+) play crucial roles in sensing changes in DNA structure, and several function in the maintenance of telomeres. When the mammalian homologue of S. pombe Rad9 was inactivated, increases in chromosome end-to-end associations and frequency of telomere loss were observed. This telomere...
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