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Article

A dominant allele of PDR1 alters transition metal resistance in yeast.

The Journal of biological chemistry - 10 Jan 2003

Tuttle Marie Spencer, Radisky Derek, Li Liangtao, Kaplan Jerry

Abstract excerpt

A yeast mutant was found to have defective growth on low iron medium despite a normal high affinity iron transport system. The phenotype results from a gain of function mutation in PDR1, which encodes a transcription factor that acts as a regulator of pleiotropic drug resistance in Saccharomyces cerevisiae. The mutant allele, PDR1(R821H), was found to result in increased expression of at least 19 genes, three of...

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PMID: 12411429
DOI: 10.1074/jbc.M209631200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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