Article
Analysis of second-site mutations that suppress the multiple drug resistance phenotype of the yeast PDR1-7 allele.
Gene - 29 Dec 1995
McGuire T M, Carvajal E, Katzmann D, Wagner M, Moye-Rowley W S, Goffeau A, Golin J
Abstract excerpt
The yeast PDR1 locus encodes a member of the C6 zinc cluster family of transcriptional regulatory proteins. Among the targets of PDR1 is the yeast PDR5 locus. The product of this gene is a member of the ATP-binding cassette (ABC) transmembrane protein family and plays a major role in inhibitor ef...
Topics
- ATP-Binding Cassette Transporters
- Alleles
- Base Sequence
- DNA Primers
- DNA-Binding Proteins
- Drug Resistance, Multiple
- Gene Expression Regulation, Fungal
- Genes, Suppressor
- Macromolecular Substances
- Molecular Sequence Data
- RNA, Messenger
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Trans-Activators