Article
Gain-of-function mutations identify amino acids within transmembrane domains of the yeast vacuolar transporter Zrc1 that determine metal specificity.
The Biochemical journal - 13 Aug 2009
Lin Huilan, Burton Damali, Li Liangtao, Warner David E, Phillips John D, Ward Diane McVey, Kaplan Jerry
Abstract excerpt
Cation diffusion facilitator transporters are found in all three Kingdoms of life and are involved in transporting transition metals out of the cytosol. The metals they transport include Zn2+, Co2+, Fe2+, Cd2+, Ni2+ and Mn2+; however, no single transporter transports all metals. Previously we showed that a single amino acid mutation in the yeast vacuolar zinc transporter Zrc1 changed its substrate specificity...
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