Article
PDR2 Gain-of-function mutations eliminate the need for Pdr1 and require the UBP6 product for resistance to translational inhibitors.
Current genetics - 1 Apr 2002
Keeven James, Ko Daejin, Shallom Joshua, Uccelini Beth, Golin John
Abstract excerpt
The yeast YRR1 gene was identified as a sequence encoding a protein that is related in structure to the Pdr1 and Pdr3 zinc cluster transcription factors. Dominant gain-of-function mutations were recovered that cause a multidrug resistance to inhibitors transported by the SNQ2 and YOR1 proteins. It was previously reported by others that null mutations in YRR1 cause hypersensitivity to these agents. In this study,...
Topics
- ATP-Binding Cassette Transporters
- Anisomycin
- Antifungal Agents
- Base Sequence
- Chloramphenicol
- DNA, Fungal
- DNA-Binding Proteins
- Drug Resistance, Multiple, Fungal
- Endopeptidases
- Fungal Proteins
- Membrane Proteins
- Phenotype
- Protein Synthesis Inhibitors