Article
Molecular and phenotypic characterization of yeast PDR1 mutants that show hyperactive transcription of various ABC multidrug transporter genes.
Molecular & general genetics : MGG - 1 Oct 1997
Carvajal E, van den Hazel H B, Cybularz-Kolaczkowska A, Balzi E, Goffeau A
Abstract excerpt
Mutations at the yeast PDR1 transcriptional regulator locus are responsible for overexpression of the three ABC transporter genes PDR5, SNQ2 and YOR1, associated with the appearance of multiple drug resistance. The nucleotide sequences of 13 alleles of PDR1, comprising 6 multidrug resistance muta...
Topics
- ATP-Binding Cassette Transporters
- Alleles
- DNA-Binding Proteins
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Genome, Fungal
- Membrane Proteins
- Mutagenesis
- Phenotype
- Polymorphism, Genetic
- Promoter Regions, Genetic
- RNA, Messenger
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Trans-Activators
- Transcription Factors
- Transcriptional Activation