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Article

SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4.

The Journal of biological chemistry - 15 Aug 2003

Lin Xia, Liang Min, Liang Yao-Yun, Brunicardi F Charles, Feng Xin-Hua

Abstract excerpt

Tumor suppressor Smad4/DPC4 is a central intracellular signal transducer for transforming growth factor-beta (TGF-beta) signaling. We recently reported that transcriptional potential of Smad4 was regulated by SUMOylation in transfected HeLa cells (1), but the precise mechanism and function of Smad4 SUMOylation in TGF-beta signaling remain to be elucidated. Here, we describe the regulation of TGF-beta signaling by...

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Identifiers

PMID: 12813045
DOI: 10.1074/jbc.C300112200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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