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Article

HDAC8 cooperates with SMAD3/4 complex to suppress SIRT7 and promote cell survival and migration

13 Jan 2020

Abstract excerpt

NAD+-dependent SIRT7 deacylase plays essential roles in ribosome biogenesis, stress response, genome integrity, metabolism and aging, while how it is transcriptionally regulated is still largely unclear. TGF-β signaling is highly conserved in multicellular organisms, regulating cell growth, cancer stemness, migration and invasion. Here, we demonstrate that histone deacetylase HDAC8 forms complex with SMAD3/4...

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PMID: 31970414
DOI: 10.1093/nar/gkaa039

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