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Article

A population of hematopoietic stem cells derives from GATA4-expressing progenitors located in the placenta and lateral mesoderm of mice.

Haematologica - 1 Apr 2017

Cañete Ana, Carmona Rita, Ariza Laura, Sánchez María José, Rojas Anabel, Muñoz-Chápuli Ramón

Abstract excerpt

GATA transcription factors are expressed in the mesoderm and endoderm during development. GATA1-3, but not GATA4, are critically involved in hematopoiesis. An enhancer (G2) of the mouse Gata4 gene directs its expression throughout the lateral mesoderm and the allantois, beginning at embryonic day 7.5, becoming restricted to the septum transversum by embryonic day 10.5, and disappearing by midgestation. We have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28057738
DOI: 10.3324/haematol.2016.155812
PMCID: PMC5395105

Genes

GATA4
GATA1

Provenance

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